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. 2020 Mar 24;64(4):e02045-19. doi: 10.1128/AAC.02045-19

FIG 3.

FIG 3

Paenipeptin analogue 1 in combination with clarithromycin or rifampin was efficacious against Escherichia coli FDA-CDC AR 0494 in a murine thigh infection model. Treatment groups (antimicrobial injection time, hours postinfection): PBS, phosphate-buffered saline; PMXB_7.5, 7.5 mg/kg polymyxin B (2 h); CLR_60, 60 mg/kg clarithromycin (2 and 5 h); RIF_2.5, 2.5 mg/kg rifampin (2 and 5 h); RIF_5, 5 mg/kg rifampin (2 and 5 h); Paen_40: 40 mg/kg analogue 1 (2 h); Paen_60, 60 mg/kg analogue 1 (2 h); Paen_60+CLR_60, 60 mg/kg analogue 1 (2 h) plus 60 mg/kg clarithromycin (2 h and 5 h); Paen_40+RIF_5, 40 mg/kg analogue 1 (2 h) plus 5 mg/kg rifampin (2 h and 5 h); Paen_60+RIF_2.5, 60 mg/kg analogue 1 (2 h) plus 2.5 mg/kg rifampin (2 h and 5 h); Paen_60+RIF_5, 60 mg/kg analogue 1 (2 h) plus 5 mg/kg rifampin (2 h and 5 h). Statistical significance between the antimicrobial treatment groups and the PBS control group is indicated by an asterisk(s) (*, P < 0.05; ***, P < 0.001).