TABLE 1.
MIC values of polymyxin B, clarithromycin, rifampin, and paenipeptin analogues 1 and 15 against polymyxin-resistant pathogens from the FDA-CDC Antimicrobial Resistance Isolate Bank
| E. coli strain | MIC (μg/ml) values for:a |
||||
|---|---|---|---|---|---|
| Polymyxin B | Clarithromycin | Rifampin | Analogue 1 | Analogue 15 | |
| FDA-CDC AR 0350 | 4–8 | >32 | 16 | 16–32 | 16 |
| FDA-CDC AR 0493 | 8–16 | >32 | 16 | 32 | 16 |
| FDA-CDC AR 0494 | 8 | ≥32 | 16–32 | 16–32 | 8–16 |
| FDA–CDC AR 0495 | 4–16 | >32 | 8–16 | 16–32 | 16 |
| ATCC 25922 | ≤0.5 | >32 | 8–16 | 8 | 8–16 |
a
The MIC represents the range of individual concentrations measured from at least three independent experiments.