TABLE 2.
Candida auris antifungal combination testing of various drugs in combination with 5FCa
| Drug(s) | MIC (mg/liter) for Candida auris strain: |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 17-1 | 17-12 | 17-13 | 17-14 | 17-15 | 17-16 | 17-17 | 17-18 | 18-1 | 18-2 | 18-5 | 18-13 | 18-14 | 18-15 | 16-1 | |
| AMB | 1 | 2 | >2 | 1 | >2 | >2 | 1 | >2 | 1 | 2 | 2 | 0.5 | >2 | 2 | 0.5 |
| 5FC | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | >32 | 1 | 1 | >32 | 1 | 1 | 1 |
| AMB-5FC | 0.2/1 | 0.25/1 | 0.25/1 | 0.25/1 | 0.25/1 | 0.25/1 | 0.015/1 | 0.25/1 | NA | 0.015/1 | 0.25/1 | NAb | 0.12/1 | 0.12/1 | 0.25/1 |
| AFG | >4 | >4 | 2 | >4 | >4 | >4 | 0.5 | 2 | 0.5 | >4 | 4 | 0.5 | 2 | 4 | 0.12 |
| 5FC | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | >32 | 1 | 1 | >32 | 1 | 1 | 1 |
| AFG-5FC | 0.0078/1 | 0.0078/1 | 0.12/1 | 0.0078/1 | 0.015/2 | 0.0078/1 | 0.12/1 | 0.5/0.25 | NA | 0.0078/1 | 0.12/1 | 0.5/0.25 | 0.12/1 | 0.12/1 | 0.12/1 |
| CAS | >4 | >4 | >4 | >4 | >4 | >4 | >4 | >4 | >4 | >4 | >4 | >4 | >4 | >4 | 0.12 |
| 5FC | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | >32 | 1 | 1 | >32 | 1 | 1 | 1 |
| CAS-5FC | 0.0078/1 | 0.0078/1 | 0.12/1 | 0.0078/1 | 0.015/2 | 0.0078/1 | 0.5/0.25 | 0.12/1 | NA | 0.0078/1 | 0.25/2 | NA | 0.12/1 | 0.12/1 | 0.12/1 |
| MFG | >4 | >4 | 0.25 | >4 | >4 | >4 | 0.12 | 0.25 | 0.25 | >4 | 0.25 | 0.25 | 1 | 0.25 | 0.12 |
| 5FC | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | >32 | 1 | 1 | >32 | 1 | 1 | 1 |
| MFG-5FC | 0.12/1 | 0.06/0.5 | 0.12/1 | 0.12/1 | 0.12/1 | 0.12/1 | 0.12/1 | 0.25/0.12 | 0.1/0.06 | 0.12/1 | 0.12/1 | 0.1/0.06 | 0.12/1 | 0.12/1 | 0.12/1 |
| POS | 0.5 | 0.12 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.12 | 1 | >1 | 1 | 1 | 0.25 |
| 5FC | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | >32 | 1 | 1 | >32 | 1 | 1 | 1 |
| POS-5FC | 0.0078/1 | 0.06/0.12 | NA | 0.0078/1 | 0.12/1 | 0.12/1 | 0.0078/1 | 0.0078/1 | 0.12/1 | 0.0078/1 | 0.12/1 | 0.5/1 | 0.0078/1 | 0.25/2 | 0.12/1 |
| ISA | >2 | 0.12 | >2 | >2 | >2 | >2 | >2 | >2 | 1 | >2 | 2 | >2 | >2 | >2 | 0.06 |
| 5FC | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | >32 | 1 | 1 | >32 | 1 | 1 | 1 |
| ISA-5FC | 0.0078/1 | 0.12/1 | 0.12/1 | 0.06/1 | 0.12/1 | 0.0078/1 | 0.0078/1 | 0.0078/1 | 1/1 | 0.0078/1 | 0.12/1 | NA | 0.0078/1 | 0.25/2 | 0.12/1 |
| ITC | >1 | 0.06 | 0.5 | 0.5 | 0.5 | 0.5 | >1 | >1 | >1 | 0.5 | 1 | >1 | >1 | >1 | 0.5 |
| 5FC | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | >32 | 1 | 1 | >32 | 1 | 1 | 1 |
| ITC-5FC | 0.03/1 | 0.03/1 | 0.06/1 | 0.003/1 | 0.06/1 | 0.003/1 | 0.003/1 | 0.06/1 | 0.5/1 | 0.003/1 | 0.06/1 | 0.5/1 | 0.003/1 | 0.12/2 | 0.03/0.5 |
| VRC | >2 | 1 | >2 | >2 | >2 | >2 | >2 | >2 | >2 | >2 | >2 | >2 | >2 | >2 | 0.12 |
| 5FC | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | >32 | 1 | 1 | >32 | 1 | 1 | 1 |
| VRC-5FC | 0.015/1 | 0.12/0.5 | 0.25/1 | 0.015/1 | 0.25/1 | 0.015/1 | 0.015/1 | 0.015/1 | 1/1 | 0.015/1 | 0.25/1 | NA | 0.015/1 | 0.5/2 | 0.25/1 |
a
The details of test methods and 100% inhibition endpoints are provided in Materials and Methods.
b
NA, not available.