TABLE 2.

Growth-inhibitory potency of TBAJ-876 against clinical isolates of the M. abscessus complex^a

Isolateb	M. abscessus subsp.	erm(41) sequevarc	Clarithromycin susceptibilityc	MIC (μM)
				TBAJ-876	BDQ
Bamboo	abscessus	C28	Sensitive	0.46	0.55
M9	abscessus	T28	Resistant	0.30	0.36
M111	massiliense	Deletion	Sensitive	0.30	0.31
M199	abscessus	T28	Resistant	0.43	0.55
M232	bolletii	T28	Resistant	0.45	0.56
M337	abscessus	T28	Resistant	0.31	0.44
M421	abscessus	T28	Resistant	0.14	0.15
M422	abscessus	T28	Resistant	0.30	0.28
M506	bolletii	C28	Sensitive	0.30	0.42

^aThe experiment was carried out three times independently, and the MICs are displayed as mean values. BDQ was used as a positive control.

^bM. abscessus Bamboo is a clinical isolate whose genome characterization was described previously (51). The other clinical isolates were identified to the species level and characterized as described previously (52).

^cerm(41) is the methylase gene responsible for inducible clarithromycin resistance. The “C28” and “deletion” sequevars confer susceptibility to clarithromycin, while the “T28” sequevar confers inducible resistance against clarithromycin (26, 27).