TABLE 3.
Comparison of ritonavir pharmacokinetics in the 2nd trimester versus postpartum and in the 3rd trimester versus postpartuma
| PK parameter | Median value for group (IQR) |
Comparison of 2T/PP |
Comparison of 3T/PP |
||||
|---|---|---|---|---|---|---|---|
| 2T (n = 8) | 3T (n = 28) | PP (n = 22) | GMR (90% CI) | P value | GMR (90% CI) | P value | |
| RTV AUC0–12 (μg · h/ml) | 2.52 (1.35, 4.10) | 3.68 (2.76, 5.64) | 4.86 (2.73, 6.60) | 0.51 (0.28, 0.91) | 0.09 | 0.72 (0.55, 0.95) | 0.005 |
| RTV CL/F (liters/h) | 47.16 (24.61, 74.15) | 27.20 (17.74, 36.22) | 20.63 (15.15, 36.72) | 1.98 (1.10, 3.56) | 0.06 | 1.38 (1.05, 1.82) | 0.009 |
| RTV T1/2 (h) | 3.71 (3.06, 10.92) | 4.08 (3.47, 6.65) | 4.92 (3.03, 6.64) | 1.05 (0.18, 6.14) | 1.00 | 1.45 (0.57, 3.69) | 0.520 |
| RTV Cmin (μg/ml) | 0.07 (0.05, 0.12) | 0.12 (0.05, 0.15) | 0.10 (0.05, 0.20) | 0.49 (0.24, 0.99) | 0.08 | 1.08 (0.87, 1.33) | 0.720 |
| RTV Clast (μg/ml) | 0.09 (0.06, 0.16) | 0.13 (0.06, 0.24) | 0.18 (0.08, 0.26) | 0.45 (0.20, 1.03) | 0.08 | 0.83 (0.63, 1.10) | 0.250 |
| RTV Cmax (μg/ml) | 0.41 (0.25, 0.73) | 0.64 (0.51, 1.07) | 0.77 (0.51, 1.08) | 0.65 (0.37, 1.12) | 0.30 | 0.83 (0.61, 1.11) | 0.475 |
| RTV C0 (μg/ml) | 0.13 (0.06, 0.24) | 0.16 (0.11, 0.31) | 0.19 (0.09, 0.41) | 0.59 (0.31, 1.10) | 0.30 | 0.87 (0.62, 1.22) | 0.134 |
| RTV C12 (μg/ml) | 0.12 (0.05, 0.29) | 0.16 (0.05, 0.20) | 0.19 (0.08, 0.26) | 0.71 (0.24, 2.14) | 0.69 | 0.70 (0.53, 0.91) | 0.029 |
a
P values were determined by a Wilcoxon rank sum test. 2T, second trimester; 3T, third trimester; PP, postpartum; IQR, interquartile range; AUC0–12, area under the concentration-versus-time curve from time zero to 12 h postdose; CL/F, apparent oral clearance; Cmin, minimum concentration; Cmax, maximum concentration; T1/2, elimination half-life; Clast, last observed quantifiable concentration; C0, initial concentration at time zero; C12, concentration at 12 h postdose. Values in boldface type are significant P values (<0.1).