TABLE 1.

Synergic compounds at 0.1 mM with AmB 0.03 μg/ml against C. neoformans

Compound name	Amount (μg/ml)	Therapeutic class	Target/action mechanism	Compound inhibition (%)	Combination inhibition (%)
Atracurium besylate	124	Neuromuscular	Nondepolarizing neuromuscular blocking agent. Antagonizes the neurotransmitter action of acetylcholine	40	95
Erythromycin	73	Infectiology/metabolism	Inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits	15	90
Riluzole hydrochloride	27	Central nervous system	Inhibitory effect on glutamate release, inactivation of voltage-dependent sodium channels, and interference in intracellular events that follow transmitter binding at excitatory amino acid receptors	25	95
Nortriptyline hydrochloride	30	Central nervous system	Inhibits the reuptake of the neurotransmitter serotonin at the neuronal membrane or acts at beta-adrenergic receptors	30	90
Chenodiol	40	Gastroenterology	Suppresses hepatic synthesis of both cholesterol and cholic acid, gradually replacing the latter and its metabolite, deoxycholic acid, in an expanded bile acid pool	30	90
Thioguanosine	31	Metabolism/oncology	Antineoplastic action. Inhibits the synthesis of DNA and RNA of cells.	40	85
Diflorasone diacetate	49	Endocrinology	Synthetic glucocorticoid that binds to the glucocorticoid receptor (GR) in the cytoplasm.	30	90
Oxiconazole nitrate	49	Infectiology/metabolism	Inhibits ergosterol biosynthesis, inhibits DNA synthesis, and suppresses the intracellular concentrations of ATP	5	95
Nisoldipine	39	Cardiovascular	By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. Inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes	25	95
Promazine hydrochloride	32	Central nervous system	Antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors	20	80
Chlorcyclizine hydrochloride	33	Allergology/central nervous system	Histamine H1 receptor	15	100
Demeclocycline hydrochloride	50	Metabolism	Inhibits the translation by binding to the 30S and 50S ribosomal subunit, impairing protein synthesis.	35	90
Cloperastine hydrochloride	36	Respiratory	Not identified	5	90
Glimepiride	49	Endocrinology	Binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface. Reduces potassium conductance causing depolarization of the membrane and stimulates calcium ion influx through voltage-sensitive calcium channels. Induces the secretion of insulin	5	80