TABLE 2.
Antimicrobial activities of tedizolid and comparator agents against 1,342 E. faecalis, 916 E. faecium, and resistant phenotypes from bloodstream and intra-abdominal infections in European and U.S. hospitalized patients
| Organism/phenotype and antimicrobial agenta | MIC (mg/liter) |
Susceptibility (%) according tob: |
||||
|---|---|---|---|---|---|---|
| CLSI |
EUCAST |
|||||
| MIC50 | MIC90 | S | R | S | R | |
| Enterococcus faecalis (n = 1,342) | ||||||
| Ampicillin | 1 | 1 | 100 | 0.0 | 100 | 0.0 |
| Daptomycin | 0.5 | 1 | 99.6 | 0.0 | – | – |
| Gentamicin | ≤128 | >256 | – | – | 70.0 | 30.0 |
| Linezolid | 1 | 2 | 99.9 | 0.1 | 99.9 | 0.1 |
| Tedizolid | 0.25 | 0.25 | 99.9 | – | – | – |
| Vancomycin | 1 | 2 | 97.8 | 2.1 | 97.8 | 2.2 |
| HLAR (n = 402) | ||||||
| Ampicillin | 1 | 2 | 100 | 0.0 | 100 | 0.0 |
| Daptomycin | 0.5 | 1 | 99.8 | 0.0 | – | – |
| Gentamicin | >256 | >256 | – | – | 0.0 | 100 |
| Linezolid | 1 | 2 | 99.5 | 0.2 | 99.8 | 0.2 |
| Tedizolid | 0.25 | 0.25 | 99.8 | – | – | – |
| Vancomycin | 1 | 1 | 94.5 | 5.2 | 94.5 | 5.5 |
| VRE (n = 28) | ||||||
| Ampicillin | 1 | 2 | 100 | 0.0 | 100 | 0.0 |
| Daptomycin | 0.5 | 1 | 100 | 0.0 | – | – |
| Gentamicin | >256 | >256 | – | – | 25.0 | 75.0 |
| Linezolid | 1 | 2 | 100 | 0.0 | 100 | 0.0 |
| Tedizolid | 0.25 | 0.5 | 100 | – | – | – |
| Vancomycin | >16 | >16 | 0.0 | 100 | 0.0 | 100 |
| VRE-HLAR (n = 21) | ||||||
| Ampicillin | 1 | 2 | 100 | 0.0 | 100 | 0.0 |
| Daptomycin | 0.5 | 1 | 100 | 0.0 | – | – |
| Gentamicin | >256 | >256 | – | – | 0.0 | 100 |
| Linezolid | 1 | 2 | 100 | 0.0 | 100 | 0.0 |
| Tedizolid | 0.25 | 0.25 | 100 | – | – | – |
| Vancomycin | >16 | >16 | 0.0 | 100 | 0.0 | 100 |
| Daptomycin (MIC, ≥2 mg/liter) (n = 44) | ||||||
| Ampicillin | 1 | 1 | 100 | 0.0 | 100 | 0.0 |
| Daptomycin | 2 | 4 | 88.6 | – | – | – |
| Gentamicin | ≤128 | >256 | – | – | 75.0 | 25.0 |
| Linezolid | 1 | 2 | 100 | 0.0 | 100 | 0.0 |
| Tedizolid | 0.25 | 0.25 | 100 | – | – | – |
| Vancomycin | 1 | 2 | 100 | 0.0 | 100 | 0.0 |
| Enterococcus faecium (n = 916) | ||||||
| Ampicillin | >16 | >16 | 15.8 | 84.2 | 14.6 | 84.2 |
| Daptomycin | 1 | 2 | 99.8c | 0.2 | – | – |
| Gentamicin | ≤128 | >256 | – | – | 74.8 | 26.2 |
| Linezolid | 1 | 2 | 99.1 | 0.4 | 99.6 | 0.4 |
| Tedizolid | 0.25 | 0.5 | – | – | – | – |
| Vancomycin | 1 | >16 | 61.9 | 37.4 | 61.9 | 38.1 |
| HLAR (n = 231) | ||||||
| Ampicillin | >16 | >16 | 4.3 | 95.7 | 3.5 | 95.7 |
| Daptomycin | 1 | 2 | 99.6c | 0.4 | – | – |
| Gentamicin | >256 | >256 | – | – | 0 | 100 |
| Linezolid | 1 | 2 | 98.7 | 0.9 | 99.1 | 0.9 |
| Tedizolid | 0.25 | 0.5 | – | – | – | – |
| Vancomycin | 1 | >16 | 66.2 | 32.5 | 66.2 | 33.8 |
| VRE (n = 343) | ||||||
| Ampicillin | >16 | >16 | 1.2 | 98.8 | 0.6 | 98.8 |
| Daptomycin | 1 | 2 | 99.4c | 0.6 | – | – |
| Gentamicin | ≤128 | >256 | – | – | 78.1 | 21.9 |
| Linezolid | 1 | 2 | 99.4 | 0.3 | 99.7 | 0.3 |
| Tedizolid | 0.25 | 0.25 | – | – | – | – |
| Vancomycin | >16 | >16 | 0 | 100 | 0 | 100 |
| VRE-HLAR (n = 75) | ||||||
| Ampicillin | >16 | >16 | 0 | 100 | 0 | 100 |
| Daptomycin | 1 | 2 | 98.7c | 1.3 | – | – |
| Gentamicin | >256 | >256 | – | – | 0 | 100 |
| Linezolid | 1 | 2 | 100 | 0 | 100 | 0 |
| Tedizolid | 0.25 | 0.5 | – | – | – | – |
| Vancomycin | >16 | >16 | 0 | 100 | 0 | 100 |
| Daptomycin (MIC, ≥2 mg/liter) (n = 369) | ||||||
| Ampicillin | >16 | >16 | 15.7 | 84.3 | 14.1 | 84.3 |
| Daptomycin | 2 | 2 | 99.5c | 0.5 | – | – |
| Gentamicin | ≤128 | >256 | – | – | 71.3 | 28.7 |
| Linezolid | 1 | 2 | 98.4 | 0.8 | 99.2 | 0.8 |
| Tedizolid | 0.25 | 0.5 | – | – | – | – |
| Vancomycin | 1 | >16 | 68.3 | 31.2 | 68.3 | 31.7 |
| VRE and daptomycin (MIC, ≥2 mg/liter) (n = 115) | ||||||
| Ampicillin | >16 | >16 | 1.7 | 98.3 | 0.9 | 98.3 |
| Daptomycin | 2 | 2 | 98.3c | 1.7 | – | – |
| Gentamicin | ≤128 | >256 | – | – | 73.9 | 26.1 |
| Linezolid | 1 | 2 | 98.3 | 0.9 | 99.1 | 0.9 |
| Tedizolid | 0.25 | 0.25 | – | – | – | – |
| Vancomycin | >16 | >16 | 0 | 100 | 0 | 100 |
| HLAR-VRE and daptomycin (MIC, ≥2 mg/liter) (n = 30) | ||||||
| Ampicillin | >16 | >16 | 0 | 100 | 0 | 100 |
| Daptomycin | 2 | 2 | 96.7c | 3.3 | – | – |
| Gentamicin | >256 | >256 | – | – | 0.0 | 100 |
| Linezolid | 1 | 2 | 100 | 0 | 100 | 0 |
| Tedizolid | 0.25 | 0.25 | – | – | – | – |
| Vancomycin | >16 | >16 | 0 | 100 | 0 | 100 |