TABLE 4.

Kinetic parameters of vaborbactam and avibactam inhibition of NCF hydrolysis by KPC-2 and the L169P mutant

Enzyme	Avibactam				Vaborbactam
	k2/K, M−1 s−1	k−2, s−1	Kd, μM	Ki, μM	k2/K, M−1 s−1	k−2, s−1	Kd, μM	Ki, μM
KPC-2	2.3 ± 0.2 × 104	3.3 ± 0.1 × 10−4	0.014 ± 0.001		5.5 ± 0.5 × 103	4.3 ± 0.6 × 10−5	0.0078 ± 0.0011
KPC-2 L169P				0.89 ± 0.03				0.19 ± 0.02