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IC50s of vaborbactam and avibactam inhibition of ceftazidime hydrolysis by KPC-2 and the D179Y mutanta
| Enzyme | IC50, μM |
|
|---|---|---|
| Avibactam | Vaborbactam | |
| KPC-2 | 0.47 ± 0.02 | 0.94 ± 0.02 |
| KPC-2 D179Y | 8.9 ± 0.9 | 1.9 ± 0.3 |
Concentrations of 100 μM and 10 μM ceftazidime were used to determine IC50s for KPC-2 and its D179Y mutant, respectively.
