TABLE 1.
In vitro activity of rezafungin against Nordic Candida isolates and C. auris isolates from India as determined by EUCAST E.Def 7.3.1
| Yeast | n | No. with MIC (mg/liter)a: |
MIC range (mg/liter) | MIC50 (mg/liter) | MIC90 (mg/liter) | WT-ULb (mg/liter) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.016 | 0.03 | 0.06 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | ≥8 | Visual | 97.5% | 99% | |||||
| Nordic isolates | |||||||||||||||||
| C. albicans | 569 | 28 | 221 | 282 | 27 | 8 | 2 | 1 | 0.016 to 1 | 0.06 | 0.06 | 0.125 | 0.125 | 0.125 | |||
| C. glabrata | 328 | 1 | 87 | 214 | 16 | 5 | 1 | 4 | 0.03 to 2 | 0.125 | 0.125 | 0.25 | 0.25 | 0.25 | |||
| C. krusei | 82 | 2 | 26 | 47 | 6 | 1 | 0.03 to 1 | 0.125 | 0.125 | 0.25 | 0.25 | 0.25 | |||||
| C. tropicalis | 73 | 2 | 19 | 43 | 7 | 1 | 1 | 0.03 to 2 | 0.125 | 0.25 | 0.25 | 0.25 | 0.25 | ||||
| C. dubliniensis | 68 | 8 | 28 | 29 | 1 | 1 | 1 | 0.03 to 2 | 0.06 | 0.125 | 0.25 | 0.25 | 0.25 | ||||
| C. parapsilosis | 61 | 8 | 40 | 13 | 1 to 4 | 2 | 4 | 4 | 4 | 4 | |||||||
| C. lusitaniae | 20 | 10 | 8 | 2 | 0.125 to 0.4 | 0,125 | 0,25 | 0.5 | 0.25 | 0.25 | |||||||
| S. cerevisiae | 15 | 6 | 8 | 1 | 0.125 to 0.5 | 0.25 | 0.25 | 0.5 | 0.5 | 0.5 | |||||||
| Other Candida | 55 | 2 | 16 | 7 | 1 | 11 | 11 | 6 | 1 | 0.03 to >4 | 0.5 | 2 | ND | ND | ND | ||
| Other yeast | 22 | 2 | 2 | 1 | 1 | 2 | 14 | 0.03 to >4 | >4 | >4 | ND | ND | ND | ||||
| Indian isolates | |||||||||||||||||
| C. auris | 122 | 3 | 22 | 63 | 16 | 7 | 3 | 8 | 0.06 to 16 | 0.25 | 1 | 0.5 | 0.5 | 0.5 | |||
a
MIC values above the WT-UL are in boldface.
b
The WT-UL was determined visually and statistically using the ECOFFinder program, including 97.5% and 99% of the wild-type population, respectively. The ECOFFinder program requires at least one isolate with an MIC at least one step above the modal MIC to calculate an upper limit. ND, not done.