TABLE 1.
Demographics and characteristics by Clostridioides difficile infection groupa
| Patient characteristicb | Data for infection groupc: |
|
|---|---|---|
| CDI (n = 2,356) | No CDI (n = 503,712) | |
| No. with hospital onset | 1,655 | |
| No. with community onset, health care facility associated (within 30 days of discharge) | 701 | |
| Age (mean [SD]) (yr) | 62.95 (17.84) | 60.21 (18.87) |
| Male | 1,127 (47.8) | 231,215 (45.9) |
| 1-yr mortality | 704 (29.9) | 62,461 (12.4) |
| 30-day readmission | 148 (6.3) | 11,390 (2.3) |
| Length of stay (mean [SD]) (days) | 14.72 (15.74) | 3.84 (4.54) |
| Current ICU admission | 928 (39.4) | 80,623 (16.0) |
| Medical-surgical ward admission within 90 days | 896 (38.0) | 120,212 (23.9) |
| ICU admission, prior 90 days | 315 (13.4) | 33,480 (6.6) |
| Antibiotic use, prior 60 days | 1,931 (82.0) | 80,379 (16.0) |
| Gastric acid suppression | 1,645 (69.8) | 225,061 (44.7) |
| Steroids | 652 (27.7) | 62,285 (12.4) |
| Nonsteroidal immunosuppression | 232 (9.8) | 13,631 (2.7) |
| White blood cell count (median [IQI]) (cells/mm3) | 6.8 (4.7–9.3) | 7.2 (5.6–9.3) |
| Absolute neutrophil count (median [IQI]) (cells/mm3) | 5.5 (3.4–8.5) | 5.4 (3.8–7.8) |
| Serum creatinine concn (median [IQI]) (mg/dl) | 1.26 (0.88–2.20) | 1.00 (0.80–1.32) |
| Gastrointestinal procedure, prior 90 days | 756 (32.1) | 36,353 (7.2) |
| Charlson comorbidity score (median [IQI]) | 6.00 (4.0, 9.0) | 4.00 (2.0, 8.0) |
| No. of comorbidities (mean [SD]) | 3.42 (2.37) | 2.42 (2.24) |
| Connective tissue disease | 151 (6.4) | 17,337 (3.4) |
| Human immunodeficiency virus | 7 (0.3) | 446 (0.1) |
| Inflammatory bowel disease | 84 (3.6) | 6,836 (1.4) |
| Solid organ transplant recipient | 29 (1.2) | 2,360 (0.5) |
| Hematological malignancy | 108 (4.6) | 3,188 (0.6) |
| Hematopoietic stem cell transplant recipient | 57 (2.4) | 646 (0.1) |
| History of malignancy | 655 (27.8) | 86,524 (17.2) |
| Cerebrovascular disease | 554 (23.5) | 96,899 (19.2) |
| Chronic pulmonary disease | 1,125 (47.8) | 209,408 (41.6) |
| Congestive heart failure | 866 (36.8) | 128,003 (25.4) |
| Cognitive impairment | 92 (3.9) | 16,481 (3.3) |
| Diabetes mellitus without complications | 838 (35.6) | 152,933 (30.4) |
| Diabetes mellitus with complications | 340 (14.4) | 49,779 (9.9) |
| Metastatic cancer | 175 (7.4) | 25,576 (5.1) |
| Mild hepatic disease | 665 (28.2) | 76,608 (15.2) |
| Severe hepatic disease | 193 (8.2) | 11,704 (2.3) |
| Myocardial infarction | 440 (18.7) | 81,554 (16.2) |
| Paraplegia | 159 (6.7) | 19,511 (3.9) |
a
Data are reported as the no. (%), unless otherwise noted.
b
IQI, 25% to 75% interquartile interval.
c
CDI, Clostridioides difficile infection.