TABLE 2.
Adjusted risk of CDI and individual antibiotics within 60 days prior to index admission in final modela
| Antibiotic | Odds ratio | 95% CIb | Pc |
|---|---|---|---|
| Ampicillin | 1.6 | 1.1–2.4 | 0.039 |
| Ampicillin-sulbactam | 1.6 | 1.1–2.3 | 0.044 |
| Cefazolin | 2.3 | 1.9–2.6 | 0.013 |
| Cefdinir | 3.5 | 1.8–6.7 | 0.036 |
| Cefepime | 2.8 | 2.1–3.6 | 0.017 |
| Cefoxitin | 4.8 | 3.8–6.3 | 0.011 |
| Ceftriaxone | 4.0 | 3.5–4.6 | 0.005 |
| Cefuroxime | 6.4 | 5.1–7.9 | 0.009 |
| Cephalexin | 2.1 | 1.5–3.0 | 0.03 |
| Clindamycin | 1.9 | 1.5–2.5 | 0.022 |
| Daptomycin | 0.4 | 0.2–0.6 | 0.034 |
| Doxycycline | 0.6 | 0.3–1.0 | 0.05 |
| Ertapenem | 2.5 | 2.0–3.2 | 0.016 |
| Antipseudomonal carbapenem | 5.1 | 4.4–6.0 | 0.003 |
| Fluoroquinolone | 3.0 | 2.7–3.5 | 0.008 |
| Linezolid | 1.2 | 1.0–1.5 | 0.047 |
| Nafcillin | 2.1 | 1.4–3.1 | 0.038 |
| Piperacillin-tazobactam | 5.1 | 4.4–6.0 | 0.002 |
| Trimethoprim-sulfamethoxazole | 2.0 | 1.6–2.6 | 0.019 |
a
Continuation of multivariable logistic regression model in Table 4, with individual antibiotics replacing the cumulative 60-day antibiotic variable.
b
CI, confidence interval.
c
P values adjusted for a 5% false-discovery rate via the Benjamini-Hochberg method.