TABLE 4.

Multivariable logistic regression for factors associated with CDI

Variable	Odds ratio	95% CIa	P
Age	1.01	1.006–1.013	<0.0001
Charlson comorbidity score	1.05	1.02–1.07	<0.0001
Chronic pulmonary disease	0.85	0.76–0.95	0.005
Diabetes mellitus	0.73	0.65–0.83	<0.0001
Malignancy	0.83	0.71–0.96	0.012
Hepatic disease	1.3	1.1–1.4	<0.0001
Hematological malignancy	3.1	2.3–4.1	<0.0001
Hematopoietic stem cell transplant	5.7	3.8–8.4	<0.0001
Corticosteroids	1.2	1.1–1.4	0.001
Gastric acid suppression	1.4	1.3–1.6	<0.0001
Recent hospitalization (past 60 days)b	2.2	1.5–3.4	<0.0001
Recent intensive care unit stay (past 60 days)c	6.5	3.8–11.3	<0.0001
Intensive care unit (current admission)	1.9	1.6–2.1	<0.0001
Gastrointestinal procedure (prior 90 days)	3.1	2.7–3.5	<0.0001
Absolute neutrophil count	1.02	1.01–1.03	<0.0001
Serum creatinine concn	1.004	1.001–1.007	0.006
Antibiotic DOT during index admissione	1.007	1.005–1.009	<0.0001d
Antibiotic DOT in the prior 60 dayse	1.128	1.122–1.134	<0.0001d

^aCI, confidence interval.

^bOR after introducing a multiplicative interaction term between recent hospitalization and any antibiotic received in the prior 60 days.

^cOR after introducing a multiplicative interaction term between recent intensive care unit stay and any antibiotic received in the prior 60 days.

^dP values adjusted for a 5% false-discovery rate via the Benjamini-Hochberg method.

^eIndividual prior antibiotics were substituted for cumulative antibiotics in the final model. See Table 2 for individual antibiotics.