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Meropenem pharmacokinetic parameters in Swiss-Webster mice
| Dose (mg/kg) | Pharmacokinetic parametera |
|||
|---|---|---|---|---|
| Total CL (liters/h/kg) | Total AUC (mg · h/liter) | Cmax (mg/liter) | t1/2 (h) | |
| 30 | 1.88 | 15.97 | 52.06 | 0.09 |
| 100 | 1.74 | 57.57 | 198.10 | 0.15 |
| 300 | 1.96 | 153.03 | 244.51 | 0.32 |
CL, clearance; AUC, area under the concentration-time curve; Cmax, maximum concentration in plasma; t1/2, half-life.
