TABLE 3.
Observed concentrations and calculated pharmacokinetic parameters calculated for all antibiotic regimens over 24 h in the chemostat experimentsc
| Isolate and regimen | Free peak concn (mg/liter) |
Free trough concn (mg/liter) |
||
|---|---|---|---|---|
| Target | Observed [means (SD)] | Target | Observed [means (SD)] | |
| ST175 (10-023) | ||||
| C/Ta | 87.6 | 85.39 (14.71) | 17.4 | 15 (2.42) |
| Colistinb | 1 | 1.90 (1.15) | NC | NC |
| ST175 (09-012) | ||||
| C/T | 87.6 | 112.8 (8.36) | 17.4 | 30.6 (5.29) |
| Colistin | 1 | 1.08 (0.33) | NC | NC |
| ST175 (07-016) | ||||
| C/T | 87.6 | 121.7 (12.05) | 17.4 | 25.5 ± 8.91 |
| Colistin | 1 | 1.72 (0.38) | NC | NC |
a
Concentration and pharmacokinetic data were targeted only for the ceftolozane component of C/T.
b
Colistin was administered as a continuous infusion; the free peak concentration is the mean steady-state concentration over the 24 h of the experiment.
c
Data are presented as the means and standard deviations. Abbreviations: C/T, ceftolozane-tazobactam; NC, not calculated.