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. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Ann Epidemiol. 2019 May 17;35:20–28.e3. doi: 10.1016/j.annepidem.2019.05.002

Table 1.

Allostatic load biomarker cut-points

Biomarker	Guideline used	AL cut-points
Metabolic system
HDL (mg/dL)	ATPIII	<50
LDL (mg/dL)	ATPIII	≥100
Waist (in)	ATPIII	>35
Glucose (mg/dL)	ATPIII	≥100 or <70
HbA1c (mmol/mol)	ADA	≥5.7
Total cholesterol (mg/dL)	ATPIII	≥160
Triglycerides (mg/dL)	ATPIII	≥150
BMI (kg/m²)	ATPIII	≥25 or <18.5
Cardiovascular system
Systolic BP (mm Hg)	AHA (JNC 7)	≥120
Diastolic BP (mm Hg)	AHA (JNC 7)	≥80
Neuroendocrine system
^*Epinephrine (pg/mL)	n/a	>77.70
^*Norepinephrine (pg/mL)	n/a	>686.30
^*Cortisol (μg/dL)	n/a	>12.69
Inflammatory system
^*Il-6 (pg/mL)	n/a	>7.85
hsCRP (mg/L)	AHA	>3

^*

75th-percentile cut-points used for biomarkers that do not have clinical guidelines; subclinical cut-points used for rest.