Figure 1. Effects of intravenous (i.v.) recombinant Phα1β administration in rats with chronic pain. (A) Time-course and (B) dose-response effect of recombinant Phα1β treatment on CCI-induced mechanical allodynia; and time course of recombinant Phα1β (0.2 mg/kg i.v.) in rats with paclitaxel-induced (C) acute or (D) chronic pain. The results are expressed as mechanical threshold (log mg), as measured by von Frey filaments. Mean and SEM values are represented by point and vertical line, respectively (12 groups with 6 rats per group, 72 rats in total). **p < 0.01 and ***p < 0.001 represent significant differences between recombinant Phα1β and PBS treatments, as analyzed by (B) one-way or (A, C and D) two-way analysis of variance followed by (B) Dunnett’s or (A) Bonferroni’s post-hoc test (n = 3 to 5).