Table 1.
Essential proteins involved in DNA metabolism targeted by anti-bacterial compounds.
| Target Protein | In Vitro Essentiality [30,45] |
Inhibitor Molecules/Classes |
|---|---|---|
| GuaB2 | Essential | diphenyl urea derivatives: DPU-2, DPU-3 [29] |
| triazole-linked mycophenolic adenine [33] | ||
| indazole sulfonamides [36] | ||
| VCC234718 5-(4-cyclohexanecarbonylpiperazine-1-sulfonyl)isoquinoline [37] | ||
| 5-amidophthalide derivative [38] | ||
| Benzoxazole derivatives [39] | ||
| OPRT | Essential | Hydroxy-2-oxo-1,2-dihydropyridine-4-carboxylic acid and its derivative 3-Benzylidene-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid [48] |
| SSB (E.coli) | Essential | Small-molecule inhibitors 1 [61] |
| DnaG (E.coli) | Essential | Phenolic monosaccharides 1 [64] |
| Bicyclic macrolide 1 [65] | ||
| DnaB (E.coli, K. Pneumoniae) | Essential | Flavonols 1 [66,67] |
| DnaN/β | Essential | Griselimycins [69] |
| GyrA | Essential | Quinolones [71] |
| GyrB | Essential | Novobiocin and coumarin derivatives [72,73] |
| TopA | Essential | m-AMSA [74] |
| Norclomipramine and Imipramin [75] | ||
| Hydroxycamptothecin derivatives [18] | ||
| LigA | Essential | Pyridochromanone [76] |
| Bis-xylofuranosylated diamines [77,79] | ||
| N-substituted tetracyclic indoles [78] | ||
| UvrABC complex | Essential | 2-(5-amino-1,3,4-thiadiazol-2-ylbenzo[f]chromen-3-one) (ATBC) [90] |
1 The compounds refer to inhibition studies performed on homologs of essential MTB proteins belonging to other bacterial species, indicated in brackets.