Figure 7.

The internalization of TAM-guided nanosystems into breast tumour: TAM is employed as an active/targeting vector due to its ability to recognize and bind specifically to ERs locating on the membrane of tumours, namely membrane-localized-ER. By conjugating TAM at the distal end of various nanosystems containing other therapeutic materials (including different drugs), selective delivery and receptor-mediated cellular internalisation of incorporated materials can be initiated [132,133,134]. Image adapted from Barclay et al. [134].