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. 2020 Mar 5;25(5):1182. doi: 10.3390/molecules25051182

Table 1.

TAM-loaded-liposomes from 2008–2019 and their applications in BC.

Composition a Physiochemical Properties b Advantages/Remarks Ref
TAM, SPC, CH, span 20 MD = 203.5 ± 19.5 nm
PI = 0.442 ± 0.03

  • Good vesicular distribution

  • DL = 53.6%

  • 4% of the drug loss over 5 weeks

  • 95% of drug was released in 30 h

 [59]
TAM, PEG-PEI PS < 270 nm
ZP = 40 mV

  • 6.7- to 7.9-fold increase in cytotoxicity

  • 86% inhibition of tumour growth in BT474 tumour bearing mice

  • No induction of skin/organ injury

 [60]
TAM, CH and lipid (DMPC and/or DSPC) PS = 482 + 0.013 nm to 887 ± 0.336 nm
Smooth surface
Multilamellar, disc shaped
ZP = −37.2 to −41.2 mV

  • Good stability

  • Sustained drug release up to 10 d after initial burst release

 [62]
TAM, Saturated SPC, phospholipid GmbH N/A

  • Significant dose-related reduction in cell viability (MCF-7 cell line)

 [63]
TAM, GEM, DPPC, CH, DMPG and DSPE-MPEG 2000c PS = 150–200 nm
Surface charge = 50 mV and −30 mV

  • Strong cell interaction after 6 h

 [61]
TAM, DAU, EPC, PEG2000-DSPE, CH, SRB EE = 95% (DAU) and 90% (TAM)
PS = 100 nm

  • Promising effects in eliminating both BC cells and cancer stem cells

 [64]
TAM, Imatinib, DPPC, MPPC EE > 70%
80% drug release with temperature-responsive behaviour (within 30 min above transition temperature 34.9 °C).

  • Synergistic growth inhibition against MCF-7 and MDA-MB-231 breast cancer cells

 [65]

a SPC = soya phosphatidylcholine, CH = cholesterol, PEI = polyethylenimine, DMPC = dimyristoyl phosphatidylcholine, DSPC = distearoyl phosphatidylcholine, GEM = gemcitabine, DPPC = 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DMPG = dimyristoyl phosphatidyglycerol, DSPE-MPEG-2000 = N-(Carbonylmethoxypoleythylene glycol-2000)-1,2,-diastearoyl-sn-glycero-3-phosphoethanolamine, DAU = daunorubicin, EPC = egg phosphatidylcholine, SRB = sulforhodamine B, MPPC = monopalmtoyl-2-hydroxy-sn-glycero-3-phosphocholine. b MD = mean diameter, PI = polydispersity index, PS = particle size, ZP = zeta-potential, EE = encapsulation efficiency, DL = drug loading. c Liposomal formulations were prepared by the TLE technique and the extrusion process.