Figure 6: Mean-variance frontiers for lung cancer subtypes.

Empirical mean-variance frontiers are plotted using Eq. 10 and observed data for various LCA subtypes (dashed lines). These are compared to predicted allowable regions in the mean-variance space based on all parameter combinations studied in Fig. 5A,C (colored regions). Blue region corresponds with allowable frontiers assuming deterministic recognition (ν = 0). Red region highlights areas of non-overlap in adaptive recognition where immune recognition is impaired (ν = 10 taken to be 10% of m₀). Green regions represent dynamics assuming immune enhancement over time (p_c,n+1 = max{p_c,∞, p_c,n + (p_c,n − p_n,∞/25)} for p_c,∞ = 0.9).