Table 3.
Associations Between Weight Change and Change in the HAI Score, Its Components, and Candidate Mortality Biomarkers After a 6-mo Intentional Weight Loss Program
| Outcome Variable | R | p Value | β (95% CI) | p Value |
|---|---|---|---|---|
| HAI (score, 0–10) | 0.37 | <.01 | 0.07 (0.03, 0.12) | <.01 |
| SBP (mmHg) | 0.33 | <.01 | 0.80 (0.26, 1.34) | <.01 |
| FVC (L) | −0.42 | <.01 | −0.02 (−0.04, −0.01) | <.01 |
| Creatinine (mg/dL) | −0.03 | .76 | −0.00 (−0.01, 0.00) | .62 |
| FBG (mg/dL) | 0.21 | .06 | 0.40 (−0.08, 0.87) | .10 |
| MoCA (score, 0–30) | −0.03 | .77 | −0.02 (−0.10, 0.06) | .65 |
| Candidate Mortality Biomarkers | ||||
| Gait Speed (m/s) | −0.29 | <.01 | −0.00 (−0.01, −0.00) | .01 |
| Grip Strength (kg) | −0.11 | .32 | −0.07 (−0.19, 0.04) | .22 |
| DSST (score, 0–93) | 0.04 | .73 | 0.06 (−0.12, 0.24) | .51 |
| FEV1 (L) | −0.43 | <.01 | −0.01 (−0.02, −0.00) | <.01 |
| Log hsIL-6 (log-pg/mL) | 0.02 | .88 | 0.00 (−0.01, 0.02) | .68 |
| Log hsCRP (log-mg/L) | 0.01 | .94 | 0.00 (−0.03, 0.03) | .83 |
| Cystatin-C (ng/mL) | 0.32 | <.01 | 0.32 (0.09, 0.55) | <.01 |
Note: Adjusted for sex. CI = Confidence interval; DSST = Digit Symbol Substitution Test; FVC = Forced vital capacity; FBG = Fasting blood glucose; FEV1 = Forced expiratory volume in 1 s; HAI = Healthy Aging Index; hsCRP = High-sensitivity C-reactive protein; hsIL-6 = High-sensitivity interleukin-6; MoCA = Montreal cognitive assessment; SBP = Systolic blood pressure.