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. 2019 Jul 12;152(3):258–276. doi: 10.1093/ajcp/aqz067

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Spectrum of bone marrow features in GATA2 deficiency, part 1. A subset of patients have bone marrows with granulomatous inflammation (A) and acid-fast bacilli-positive organisms (B), as in this patient with Mycobacterium avium-intracellulare infection (case 275). Secondary hemophagocytic lymphohistiocytosis with hemophagocytic macrophages (C) is a severe complication of GATA2 deficiency and was reported in case 258. Myelodysplasia in the setting of germline GATA2 mutation can present with hypocellular/hypoplastic bone marrow, as reported in half of submitted GATA2 cases (D, case 52). Megakaryocytic atypia and dysplasia is a common feature seen on core biopsies and aspirates of GATA2 marrows, as demonstrated in case 307 (E). Cases 307 (F and G) and 20 (H).

Spectrum of bone marrow features in GATA2 deficiency, part 1. A subset of patients have bone marrows with granulomatous inflammation (A) and acid-fast bacilli-positive organisms (B), as in this patient with Mycobacterium avium-intracellulare infection (case 275). Secondary hemophagocytic lymphohistiocytosis with hemophagocytic macrophages (C) is a severe complication of GATA2 deficiency and was reported in case 258. Myelodysplasia in the setting of germline GATA2 mutation can present with hypocellular/hypoplastic bone marrow, as reported in half of submitted GATA2 cases (D, case 52). Megakaryocytic atypia and dysplasia is a common feature seen on core biopsies and aspirates of GATA2 marrows, as demonstrated in case 307 (E). Cases 307 (F and G) and 20 (H).