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. 2019 Jul 12;152(3):258–276. doi: 10.1093/ajcp/aqz067

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Spectrum of bone marrow features in GATA2 deficiency, part 2. Very large giant abnormal megakaryocytes with detached nuclei can often be seen on aspirate smears as shown in case 138 (A). Multilineage dysplasia, with dyserythropoiesis (B, C, case 105) and dysmyelopoiesis (D, case 52; and E, case 105) is common in GATA2 deficiency-associated myelodysplastic syndrome (MDS). High-grade MDS and acute myeloid leukemia (AML) are often associated with hypercellularity as demonstrated in case 176 diagnosed as MDS-EB2 with a hypercellular marrow with marked megakaryocytic dysplasia (F). Increased CD34-positive blasts by immunohistochemistry (G), and case 20 diagnosed as AML with 80% cellularity on the core biopsy (not shown) and sheets of myeloblasts on the aspirate smear (H).

Spectrum of bone marrow features in GATA2 deficiency, part 2. Very large giant abnormal megakaryocytes with detached nuclei can often be seen on aspirate smears as shown in case 138 (A). Multilineage dysplasia, with dyserythropoiesis (B, C, case 105) and dysmyelopoiesis (D, case 52; and E, case 105) is common in GATA2 deficiency-associated myelodysplastic syndrome (MDS). High-grade MDS and acute myeloid leukemia (AML) are often associated with hypercellularity as demonstrated in case 176 diagnosed as MDS-EB2 with a hypercellular marrow with marked megakaryocytic dysplasia (F). Increased CD34-positive blasts by immunohistochemistry (G), and case 20 diagnosed as AML with 80% cellularity on the core biopsy (not shown) and sheets of myeloblasts on the aspirate smear (H).