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. 2020 Apr 20;8:e8934. doi: 10.7717/peerj.8934

Figure 5. TRAP staining in ACLT and CI rats at the 2nd and 4th week.

Figure 5

Osteoclasts were stained red, as the black arrow showed (A, C). Osteoclast activity in the subchondral bone in both two models increased at 2 weeks following treatment, but then reduced after 4 weeks (compare between A and C, B and D; and F). Significant difference was found between ACLT and CI after 2 weeks (F), which indicated that initial bone resorption may started earlier in ACLT rats. TRAP positive osteoclasts were rare in control group (E). *Statistically significant, P < 0.05. **Statistically significant, P < 0.01.