FIG 1.

Structures of ceftobiprole and PBP3. (A) Chemical structures of ceftobiprole, ceftazidime, and cefoperazone. (B) Overall structure of PaPBP3 in complex with ceftobiprole. The C-terminal catalytic transpeptidase domain (gray) and the N-terminal domain (pink) are drawn as a ribbon diagram. Atoms in ceftobiprole and the chloride ions are depicted as spheres (cyan carbons, blue nitrogens, red oxygens, yellow sulfur, and green chlorides). The catalytic S294 is shown as pink spheres and is labeled. Key secondary structural elements are labeled as in reference 4.