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Summary of mass spectrometry analysis of ceftobiprole and ceftazidime binding to PaPBP3a
| Protein | Ligand | Incubation time | Molecular mass (Da) |
|---|---|---|---|
| PaPBP3 | 58,117 | ||
| PaPBP3 | Ceftobiprole | 15 min | 58,653 (+536) |
| PaPBP3 | Ceftobiprole | 1 h | 58,653 (+536) |
| PaPBP3 | Ceftobiprole | 6 h | 58,652 (+535) |
| PaPBP3 | Ceftazidime | 15 min | 58,587 (+470) |
| PaPBP3 | Ceftazidime | 1 h | 58,589 (+472) |
| PaPBP3 | Ceftazidime | 6 h | 58,585 (+468) |
The protein/ligand concentration ratio was 1:20 for each ligand-binding experiment.
