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. 2020 Apr 21;64(5):e02479-19. doi: 10.1128/AAC.02479-19

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Copyright © 2020 Gengenbacher et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — Effect of tetracyclines on in vitro growth of M. tuberculosis H37Rv harboring essential genes under TetR control compared to wild type. (A and B) Growth inhibitory dose response of anhydrotetracycline (ATc) and doxycycline (DOX) in M. tuberculosis strains that harbor a TetR-dependent dual-control genetic switch (14) driving expression of Fum (fumarate hydratase, green symbols), Rho (transcription termination factor, orange symbols), or TrxB2 (thioredoxin reductase, blue symbols). (C) Growth inhibitory dose response of ATc and DOX against wild-type M. tuberculosis H37Rv.