FIG 4.

DOX penetration in major organs, lung lesions, and necrotic caseum of TB-infected rabbits. (A) DOX concentrations in plasma, uninvolved lung tissue, lung lesions, and major organs in 4 rabbits receiving a low-calcium 2,000 ppm DOX diet for 7 days. Mean values and standard deviations (error bars) are shown (n = 3). (B) Scatter dot plots of caseum-to-cellular DOX concentration ratios in necrotic granulomas collected from TB-infected lungs. Ratios obtained in 10 lesions from 5 infected rabbits are shown.