FIG 3.

CFU determination of clinical isolates exposed to Cpd12 given alone or in combination with imipenem (IPM) or cefoxitin (FOX). M. abscessus cultures were incubated at 30°C in CaMHB for 5 days in the presence of the indicated compounds (μg/ml) and plated on LB agar prior to CFU enumeration. Data are expressed as the mean ± SD from three independent experiments completed in triplicate. The statistical test used is a nonparametric Mann-Whitney t test in which the combinations were compared to the drugs alone. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P < 0.0001.