TABLE 1.
Interaction of Cpd6 and Cpd12 with other antibiotics against M. abscessus CIP104536T (smooth strain) assessed by checkerboards REMA in CaMHBa
| Compound | MIC (μg/ml) | Interaction with Cpd12 |
Interaction with Cpd6 |
||||
|---|---|---|---|---|---|---|---|
| FICI (mean) | SD | Outcome | FICI (mean) | SD | Outcome | ||
| Cpd12 | 0.125 | ||||||
| Cpd6 | 0.25 | ||||||
| SUT | 16 | 0.84 | ±0.27 | Indifferent | 0.62 | ±0 | Indifferent |
| IPM | 16 | 0.5 | ±0.18 | Synergistic | 0.5 | ±0 | Synergistic |
| FOX | 64 | 0.45 | ±0.14 | Synergistic | 0.44 | ±0.16 | Synergistic |
| CFZ | 0.5 | 0.88 | ±0.18 | Indifferent | 0.88 | ±0.18 | Indifferent |
a
Results are the mean of the FICI ± SD of 3 independent experiments. SUT, sutezolid; IPM, imipenem; FOX, cefoxitin; CFZ, clofazimine.