FIG 4.
Complementation of the TS INHr DLMr mutant with WT ndh restored to its DLM susceptibility. (A) Intracellular NADH/NAD balance and drug susceptibility of the above-named strains under aerobic conditions. Regarding NADH/NAD balance, data are presented as the mean ± standard deviation (SD) (n = 3). The result shown is representative of at least three independent experiments. P values are indicated in a panel. (B) Drug susceptibility of the above-named strains under anaerobic conditions. For each strain, CFU after drug exposure were normalized by CFU of the control culture (no drug) and shown as viability. Data are presented as the mean ± SD (n = 3). Data were analyzed using analysis of variance (ANOVA). *, P < 0.05 compared to control; #, P < 0.05 compared to shi at the same DLM concentration.