TABLE 1.
Distribution of mtrR mutations
| AZM MIC (μg/ml) | Distribution (no. isolates) of: |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
mtrR locus |
mtrR promoterc
|
MtrR |
|||||||||||||
| Wild type | Mosaic | Wild type | Del A | C SNP | 39A | 39T | 44H | 44R | 45D | 45G | 47L | 47A | Full length | Premature stop | |
| <2.0 | 157a | 0 | 119a | 38 | 0 | 100a | 57 | 26 | 131b | 48 | 109a | 157 | 0 | 28 | 129 |
| 2.0–4.0 | 29 | 113a | 24 | 4 | 114a | 134a | 8 | 6 | 136b | 0 | 142a | 142 | 0 | 19 | 123 |
| 8.0–16.0 | 25 | 6 | 12 | 13 | 6 | 20 | 11 | 4 | 27 | 8 | 23 | 31 | 0 | 0 | 31 |
| >16 | 4 | 0 | 0 | 4 | 0 | 4 | 0 | 0 | 4 | 0 | 4 | 4 | 0 | 0 | 4 |
a
P < 0.0001.
b
P < 0.005.
c
Del A, deletion of an adenine in the inverted repeat of the mtrR promoter; C SNP, A-to-C transversion in the inverted repeat of the mtrR promoter.