TABLE 3.

Activities of KBP-7072 and comparators against 38 colistin-resistant Acinetobacter baumannii isolates

Antimicrobial agent (no. of isolates tested)	MIC range (mg/liter)	MIC50/90 (mg/liter)	CLSIa			EUCASTa
			% S	% I	% R	% S	% I	% R
KBP-7072 (38)	0.03 to 2	0.5/1	100.0b
Tigecycline (38)	0.12 to 8	2/8	52.6c	36.9	10.5
Doxycycline (33)	≤0.06 to >8	>8/>8	39.4	3.0	57.6
Minocycline (33)	0.06 to 32	8/32	45.5	15.2	39.4
Tetracycline (33)	1 to >16	>16/>16	21.2	6.1	72.7
Ceftazidime (38)	2 to >32	>32/>32	28.9	5.3	65.8
Colistin (38)	4 to >8	>8/>8	0.0		100.0	0.0		100.0
Gentamicin (38)	0.25 to >16	>16/>16	28.9	2.6	68.4	28.9		71.1
Levofloxacin (38)	0.06 to >32	32/>32	23.7	2.6	73.7	21.1	2.6	76.3
Meropenem (38)	0.25 to >32	>32/>32	26.3	0.0	73.7	26.3	0.0	73.7
Piperacillin-tazobactam (36)	≤0.06 to >128	>128/>128	13.9	8.3	77.8

^aCriteria according to CLSI (2019) and EUCAST (2019) guidelines (22, 24).

^bPercent inhibited at ≤2 mg/liter for comparison purposes only. The highest MIC was 4 mg/liter.

^cTigecycline FDA breakpoint criteria for Enterobacteriaceae applied to A. baumannii isolates for comparison purposes only (25).