TABLE 5.

Activities of KBP-7072 and comparators against 254 tetracycline-resistant Acinetobacter baumannii isolates

Antimicrobial agent (no. of isolates tested)	MIC range (mg/liter)	MIC50/90 (mg/liter)	CLSIa			EUCASTa
			% S	% I	% R	% S	% I	% R
KBP-7072 (254)	0.03 to 4	0.5/1	98.4b
Tigecycline (254)	0.25 to 16	2/4	63.0c	32.3	4.7
Doxycycline (252)	0.25 to >8	>8/>8	41.3	3.6	55.2
Minocycline (252)	0.25 to >8	4/>8	52.8	12.3	34.9
Tetracycline (254)	>8 to >8	>8/>8	0.0	0.0	100.0
Ceftazidime (254)	4 to >16	>16/>16	9.1	5.1	85.8
Colistin (253)	≤0.5 to >8	≤0.5/2	90.5		9.5	90.5		9.5
Gentamicin (254)	0.25 to >8	>8/>8	16.9	5.9	77.2	16.9		83.1
Levofloxacin (254)	0.12 to >4	>4/>4	6.3	3.1	90.6	4.7	1.2	94.1
Meropenem (254)	0.12 to >8	>8/>8	7.4	0.4	92.1	7.5	1.2	91.3
Piperacillin-tazobactam (254)	≤0.06 to >64	>64/>64	3.9	3.5	92.5

^aCriteria according to CLSI (2019) and EUCAST (2019) guidelines (22, 24).

^bPercent inhibited at ≤2 mg/liter for comparison purposes only. The highest MIC was 4 mg/liter.

^cTigecycline FDA breakpoint criteria for Enterobacteriaceae applied to A. baumannii isolates for comparison purposes only (25).