TABLE 7.
Activities of KBP-7072 and comparator agents against ESBL- and MBL-producing Acinetobacter baumannii isolatesa
| Collection no. | MIC (mg/liter) |
β-Lactamase profile | |||||
|---|---|---|---|---|---|---|---|
| KBP-7072 | TGC | CAZ | GM | LEV | MEM | ||
| 674334 | 0.12 | 1 | >32 | ≤1 | >4 | >8 | GES-22, OXA-23, OXA-51 |
| 689088 | 0.06 | 0.5 | >32 | 8 | >4 | >8 | GES-11, OXA-23, OXA-51 |
| 764370 | 0.5 | 2 | >32 | >8 | >4 | >8 | CTX-M-15, KPC-3, OXA-23, OXA-66, OXA-9, SHV-11, TEM-1 |
| 919444 | 0.06 | 0.25 | >32 | >8 | >4 | >32 | CTX-M-115, CARB-16, OXA-72, OXA-90 TEM-1 |
| 1003787 | 0.06 | 0.5 | >32 | >16 | >16 | >32 | CTX-M-115, CARB-16, OXA-72, OXA-90 |
| 143038 | 0.5 | 2 | >16 | >8 | >4 | >8 | IMP-1, OXA-51 |
| 143675 | 0.5 | 2 | >16 | >8 | >4 | >8 | IMP-1, OXA-51 |
| 177190 | 0.12 | 0.5 | >16 | ≤2 | >4 | >8 | IMP-1, OXA-51 |
| 602690 | 0.5 | 2 | >32 | >8 | >4 | >8 | NDM-1, OXA-51, TEM-1 |
| 602847 | 1 | 2 | >32 | >8 | >4 | >8 | NDM-1, OXA-23, OXA-51, TEM-1 |
a
TGC, tigecycline; CAZ, ceftazidime; GM gentamicin; LEV, levofloxacin; MEM, meropenem; ESBL, extended-spectrum β-lactamase; MBL, metallo-β-lactamase.