. 2020 Apr 21;64(5):e02549-19. doi: 10.1128/AAC.02549-19

TABLE 2.

Comparison of the in vitro susceptibility of Plasmodium knowlesi (clone A1-H.1) and Plasmodium falciparum (clone 3D7) exposed to proguanil and selected quinolones for 2.5 life cycles

Compound	EC₅₀ (nM)^a		Fold difference^b	P^c
Compound	P. knowlesi A1-H.1 (68-h exposure)	P. falciparum 3D7 (120-h exposure)	Fold difference^b	P^c
Proguanil	2,461 ± 236	228 ± 29	10.79	0.0007
Atovaquone	0.71 ± 0.02	0.74 ± 0.09	0.99	0.1211
ELQ-300	5.31 ± 0.3	15.29 ± 1.2	0.35	0.0011
ELQ-400	1.32 ± 0.2	2.66 ± 0.3	0.50	0.0072

Means ± standard errors of the means from at least 3 experiments, each performed in duplicate.

Calculated as P. knowlesi EC₅₀/P. falciparum EC₅₀.

Calculated by comparing EC₅₀ values for P. knowlesi versus P. falciparum using Student’s two-tailed unpaired t test.