. 2020 Apr 21;64(5):e02549-19. doi: 10.1128/AAC.02549-19

TABLE 3.

Mean FICs for the drug combinations tested in this study (Fig. 1 and 2)

Combination	Mean FIC^a
Combination	P. knowlesi A1-H.1	P. falciparum 3D7
Proguanil-atovaquone	0.986 (0.949–1.024) ADD	0.545 (0.503–0.586) SYN
Proguanil–ELQ-300	1.077 (0.970–1.184) ADD	0.660 (0.619–0.700) SYN
Proguanil–ELQ-400	0.995 (0.858–1.132) ADD	0.631 (0.571–0.690) SYN
Atovaquone–ELQ-300	0.867 (0.814–0.920) M–SYN	0.816 (0.785–0.848) M–SYN
Atovaquone–ELQ-400	0.980 (0.961–0.998) ADD	1.016 (0.980–1.052) ADD

Calculated from all FICs within each experiment and for all experiments performed. Values in parentheses are 95% confidence intervals. SYN, synergistic interaction; M-SYN, moderately synergistic interaction; ADD, additive or indifferent interaction.