. 2020 Apr 21;64(5):e02408-19. doi: 10.1128/AAC.02408-19

TABLE 5.

Imipenem-relebactam MICs among Escherichia coli isolates susceptible or nonsusceptible to comparator agents

Comparator agent^a	I-R MIC								P value^b
	Susceptible to comparator agent				Nonsusceptible to comparator agent
	MIC₅₀	MIC₉₀	Range	Mean	MIC₅₀	MIC₉₀	Range	Mean
IPM	0.25	0.5	≤0.03–1.0	0.27	0.25	32	0.06 to >256	19.3	***
MEM	0.25	1.0	≤0.03–2	0.35	0.5	64	0.12 to >256	43.1	***
ETP	1.0	2	0.12–32	5.2	0.25	2	≤0.03 to >256	11.1
GEN	0.25	1.0	≤0.03 to >256	9.1	0.25	32	0.06 to >256	14.1
TZP	0.25	1.0	0.06–2	0.32	0.25	32	≤0.03 to >256	15.0	*
AMK	0.25	1	≤0.03 to >256	9.0	0.5	32	0.06 to >256	19.0	**
LVX	0.25	1	0.06–4	0.41	0.25	8	≤0.03 to >256	14.0
TGC	0.25	2	≤0.03 to >256	8.5	2	> 256	0.5 to >256	172	*
CAZ	0.5	2	0.125–2	0.59	0.25	4	0.25 to >256	12.0
CL	0.25	2	≤0.03 to >256	11.0	0.5	0.50	0.125–0.5	0.31
MIN	0.25	1.0	0.06–64	2.0	0.25	64	≤0.03 to >256	31.0	*

AMK, amikacin; CAZ, ceftazidime; CL, colistin; ETP, ertapenem; GEN, gentamicin; IPM, imipenem; I-R, imipenem-relebactam; LVX, levofloxacin; MEM, meropenem; MIN, minocycline; TGC, tigecycline; TZP, piperacillin-tazobactam.

P values as determined by Mann-Whitney test. *, P < 0.05; **, P < 0.01; ***, P ≤ 0.001.