TABLE 6.
Pharmacokinetic parameters for plasma and dialysate following intraperitoneal administration of dalbavancina
| Pharmacokinetic parameter | Value for: |
|
|---|---|---|
| Plasma (n = 3) | Dialysate (n = 3) | |
| Cmax (mg/liter) | 46.6 ± 12.6 | 1,697.0 ± 865.2 |
| Cmin (mg/liter) | 29.0 ± 16.9 | 13.3 ± 14.4 |
| Terminal half-life (h) | 522.4 ± 400.3 | 122.2 ± 55.2 |
| CL (liter/h) | 0.059 ± 0.039 | 0.034 ± 0.027 |
| V (liters) | 30.7 ± 7.5 | 7.17 ± 7.15 |
| AUC0–24 (mg·h/liter) | 973.6 ± 277.0 | 14,969.4 ± 5,786.1 |
| AUC0–day 14 (mg·h/liter) | 13,532.3 ± 4,913.4 | 69,654.3 ± 55,486.5 |
| AUC0–inf (mg·h/liter) | 41,843.2 ± 39,549.3 | 71,238.4 ± 56,492.2 |
a
Data are presented as mean ± standard deviation. Cmax, maximum plasma concentration; Cmin, minimum plasma concentration; CL, clearance; V, volume of distribution; AUC0–24, area under the curve from 0 to 24 h; AUC0–day 14, area under the curve from day 0 to day 24; AUC0–inf, area under the curve from 0 h to infinity.