TABLE 1.

MICs of β-lactams for E. coli TOP10(pTOPO-OXA-48) and variants, E. coli TOP10(pTOPO-OXA-232) and variants, and E. coli TOP10

β-Lactam	MIC (mg/liter)
	E. coli TOP10(pTOPO-OXA-48)							E. coli TOP10(pTOPO-OXA-232)							E. coli TOP10
	wt	R214S	R214G	R214L	R214K	R214D	R214E	wt	S214R	S214G	S214L	S214K	S214D	S214E
Temocillin	>256	32	32	64	128	8	8	32	256	32	64	128	8	8	8
Imipenem	0.75	0.25	0.25	0.25	0.38	0.25	0.25	0.38	0.75	0.25	0.25	0.5	0.25	0.25	0.25