FIG 2.

Effect of JNJ-6379 on preformed mature capsids. HBV-replicating HepG2.117 cells were cultured for 3 days without doxycycline, and on day 4, cells were treated with JNJ-6379 (1:5 serial dilution at 5 different concentrations) or ETV for 30 min in the presence of doxycycline. Cell lysates were incubated with or without DNase I. HBV DNA was assessed by Southern blotting. DMSO, dimethyl sulfoxide; ETV, entecavir; rcDNA, relaxed circular DNA; ssDNA, single-stranded DNA; DSL, double-stranded linear DNA.