TABLE 2.

Genes coding for resistance to antimicrobial agents, as detected by WGS of plazomicin-resistant isolates

ST, plasmids, and resistance genes detected	ARLG-2713	ARLG-2756a	ARLG-2757a	ARLG-2881b	ARLG-2882b	ARLG-3126	ARLG-3135	ARLG-3143
ST	ST16	ST147	ST147	ST395	ST395	ST231	ST231	ST231
Plasmids	IncFIB(pQil), IncFII(K), IncFIB(K)	IncFII(Pkpx1), IncFII, ColpVC	IncFII(Pkpx1), IncFII, ColpVC	IncL/M(pOXA-48), IncFIB(Mar), IncR, IncHI1B	IncL/M(pOXA-48), IncFIB(Mar), IncR	IncFIB(pQil), IncFIA, Col4401, ColKP3, IncFII(K), IncFII(pAMA1167-NDM-5), Col(BS512)	IncFIB(pQil), IncFIA, Col4401, ColKP3, IncFII(K), IncFII(pAMA1167-NDM-5)	IncFIB(pQil), IncFIA, Col4401, ColKP3, IncFII(K), IncFII(pAMA1167-NDM-5), Col(BS512)
16S rRNA methyltransferase genes	rmtF	rmtB, rmtF	rmtF	armA	None	rmtF	rmtF	rmtF
β-Lactamase genes	blaOXA-1, blaSHV-1, blaCTX-M-15c	blaOXA-181, blaSHV-11, blaTEM-1, blaCTX-M-15, blaNDM-5	blaOXA-181, blaSHV-11, blaCTX-M-15	blaOXA-48, blaSHV-11, blaTEM-1	blaOXA-48, blaSHV-11, blaTEM-1	blaOXA-232, blaSHV-1, blaTEM-1, blaCTX-M-15c	blaOXA-232, blaSHV-1, blaTEM-1, blaCTX-M-15	blaOXA-232, blaSHV-1, blaTEM-1, blaCTX-M-15c
Genes for resistance to
Aminoglycosides	aadA2	aadA2, aac(6′)-Ib	aac(6′)-Ib	None	None	aac(6′)-Ib	aadA2, aac(6′)-Ib	aadA2, aac(6′)-Ib
Fluoroquinolones	gyrA D87N, parC E84K, parE S458T	parC S80I, qnrB1c	parC S80I, qnrB1c	parC S80I, qnrS1	parC S80I, qnrS1	parC S80I, qnrS1	parC S80I, qnrS1	parC S80I, qnrS1
Macrolides, lincosamides, streptogramin B	mph(A), mrx	mph(A), mrx, erm(B)	None	msr(E), mph(E)	None	None	mph(A), erm(B)	mph(A), mrx, erm(B)
Chloramphenicol	catB4c	None	None	catA1	catA1	catA1	catA1	catA1
Rifampin	arr-2	arr-2	arr-2	None	None	arr-2	arr-2	arr-2
Sulfonamides	sul1	sul1	None	sul1	None	None	sul1	sul1
Tetracyclines	tet(A)	None	None	tet(A)	None	None	None	None
Trimethoprim	dfrA12	dfrA12, dfrA14	dfrA14	dfrA1	None	None	dfrA12	dfrA12

^aARLG-2756 and ARLG-2757 are isolates from the same patient (11).

^bARLG-2881 and ARLG-2882 are isolates from the same patient.

^cIncomplete gene present.