TABLE 3.
Time to positivity and change over time in CFU counts
| Therapy and time perioda | Mean (±SD) change in: |
|
|---|---|---|
| Time (h) to positivity (P) | Log10 CFU/ml (P)b | |
| NTZ (n) | ||
| Days 0–14 (18) | 3.2 ± 22.6 (0.56) | 0.3 ± 0.7 (0.104) |
| Days 0–2 (15) | 4.8 ± 12.1 (0.15) | |
| Days 2–14 (14) | −1.3 ± 16.8 (0.79) | |
| HREZ (n) | ||
| Days 0–14 (9) | 134.0 ± 45.2 (<0.0001) | 3.0 ± 1.3 (0.0001) |
| Days 0–2 (10) | 61.3 ± 20.3 (<0.0001) | |
| Days 2–14 (9) | 73.4 ± 37.8 (0.0004) | |
a
NTZ, nitazoxanide; HREZ is isoniazid, rifampin, ethambutol, and pyrazinamide (standard therapy).
b
For NTZ, n = 19; for HREZ, n = 10.