TABLE 1.
Susceptibility of all tested serogroups of Legionella pneumophila serogroups 1, 2, 3, 4, 5, and 6
| L. pneumophila serogroup (no. tested) | Collection dates | Antibiotic | MICs (mg/liter)a
|
||
|---|---|---|---|---|---|
| MIC range | MIC50 | MIC90 | |||
| All (100) | 1995–2014 | Omadacycline | 0.06–1 | 0.25 | 0.25 |
| Doxycycline | 0.5–1 | 1 | 1 | ||
| Telithromycin | 0.016–0.12 | 0.03 | 0.06 | ||
| Azithromycin | 0.008–0.5 | 0.12 | 0.5 | ||
| Erythromycin | 0.06–2 | 0.25 | 1 | ||
| Levofloxacin | ≤0.004–0.03 | 0.016 | 0.016 | ||
| Moxifloxacin | ≤0.004–0.06 | 0.016 | 0.016 | ||
| 1 (45) | 1995–2005 | Omadacycline | 0.06–0.5 | 0.25 | 0.25 |
| Doxycycline | 0.5–1 | 1 | 1 | ||
| Telithromycin | 0.016–0.12 | 0.03 | 0.06 | ||
| Azithromycin | 0.016–0.5 | 0.12 | 0.5 | ||
| Erythromycin | 0.06–2 | 0.12 | 1 | ||
| Levofloxacin | 0.008–0.03 | 0.016 | 0.016 | ||
| Moxifloxacin | ≤0.004–0.06 | 0.008 | 0.016 | ||
| 1 (45) | 2006–2014 | Omadacycline | 0.06–0.5 | 0.25 | 0.25 |
| Doxycycline | 0.5–1 | 1 | 1 | ||
| Telithromycin | 0.016–0.06 | 0.03 | 0.06 | ||
| Azithromycin | 0.016–0.5 | 0.12 | 0.5 | ||
| Erythromycin | 0.06–2 | 0.25 | 1 | ||
| Levofloxacin | ≤0.004–0.03 | 0.016 | 0.016 | ||
| Moxifloxacin | ≤0.004–0.06 | 0.008 | 0.016 | ||
| 2, 3, 4, 5, and 6 (10) | 1995–2014 | Omadacycline | 0.12–1 | 0.5 | 1 |
| Doxycycline | 0.5–1 | 1 | 1 | ||
| Telithromycin | 0.016–0.06 | 0.03 | 0.06 | ||
| Azithromycin | 0.008–0.5 | 0.06 | 0.5 | ||
| Erythromycin | 0.12–1 | 0.25 | 1 | ||
| Levofloxacin | ≤0.004–0.008 | 0.008 | 0.008 | ||
| Moxifloxacin | ≤0.004–0.016 | 0.008 | 0.008 | ||
a
MICs determined by broth microdilution in antibiotic concentrations from 0.004 to 128 mg/liter. Standard buffered yeast extract was used against Legionella and quality-control strains.