TABLE 2.
Final population pharmacokinetic model and internal validation for amikacin administered once daily
| Modela | Parameter | Mean (% RSEb) | Bootstrap (n = 1000) |
||
|---|---|---|---|---|---|
| Median | Percentile |
||||
| 2.5th | 97.5th | ||||
| CL (liters/h) = θ1 × (CLCR/130)θ3 | θ1 | 7.1 (7) | 7.2 | 6.2 | 8.4 |
| θ3 | 0.84 (29) | 0.86 | 0.34 | 1.26 | |
| V (liters) = θ2 × (IBW/68)θ4 | θ2 | 20.3 (8) | 20 | 15.6 | 23.2 |
| θ4 | 2.94 (34) | 3.13 | 1.27 | 5.40 | |
| Interindividual variability associated with CL (CV%) | ω2CL | 27.2 (18) | 27.2 | 12.2 | 38.2 |
| Interindividual variability associated with V (CV%) | ω2V | 33.6 (18) | 30.2 | 9.7 | 41.4 |
| Residual variability (mg/liter) | σ | 1.78 (32) | 1.75 | 1.07 | 3.09 |
a
CV, coefficient of variation. CLi = CL × (1+ηCLi). Vdi = V × (1+ηVdi).
b
RSE, relative standard error.