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. 2020 Apr 21;64(5):e02284-19. doi: 10.1128/AAC.02284-19

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Copyright © 2020 Fernandes et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — Interaction of LF with various antifungal drugs against yeasts. (A) Heatmap showing the FICI values for LF-D1 combined with each of six antifungal drugs against 22 yeast species, based on abbreviated checkerboards. (B) Summary of interactions between LF-D1 and antifungal drugs against yeast reference strains C. albicans SC5314, C. glabrata CBS138, C. neoformans H99, and C. deuterogattii R265 based on full checkerboards. (Left) FICI based on the Loewe additivity model, with values for synergy being indicated to the left of the red cutoff line; (right) micromolar squared percent based on the Bliss independence model and calculated by MacSynergy II, with values for synergy being indicated to the right of the red cutoff line; (bottom) fold decrease in the concentration of each agent required to inhibit growth when it was used in combination compared to that when it was used alone. (C) Three-dimensional dose-response surfaces generated in MacSynergy II from full checkerboard data showing significant synergy volumes, represented as peaks above the flat plane, for the combination of LF-AMB in the same four fungal species. The legends at the bottom show the cutoff values for interactions for each model.