TABLE 2.
FICI and fold change data for the combination of LF and AMB in yeast speciesa
| Species | Strain | Amphotericin B |
Lactoferrin (dairy 1) |
FICIb | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MICX (μg/ml) | MICY (μg/ml) | FICA (μg/ml) | Fold change | MICX (μg/ml) | MICY (μg/ml) | FICB (μg/ml) | Fold change | |||
| Saccharomycetes | ||||||||||
| Clavispora lusitaniae | M2002 | 0.5 | 0.125 | 0.25 | 4 | 8 | 1 | 0.125 | 8 | 0.375 |
| Pichia kudriavzevii | ATCC 6248 | 0.5 | 0.125 | 0.25 | 4 | 8 | 2 | 0.25 | 4 | 0.5 |
| Saccharomyces cerevisiae | S288c | 0.25 | 0.031 | 0.125 | 8 | 8 | 1 | 0.125 | 8 | 0.25 |
| Kluyveromyces marxianus | M1896 | 1 | 0.25 | 0.25 | 4 | 16 | 4 | 0.25 | 4 | 0.5 |
| Candida nivariensis | AMMRL1900 | 0.25 | 0.063 | 0.25 | 4 | 8 | 2 | 0.25 | 4 | 0.5 |
| Candida bracarensis | AMMRL1891 | 0.25 | 0.063 | 0.25 | 4 | 8 | 2 | 0.25 | 4 | 0.5 |
| Candida glabrata | CBS138 | 0.25 | 0.063 | 0.25 | 4 | 8 | 1 | 0.125 | 8 | 0.375 |
| Meyerozyma guilliermondii | AMMRL1830 | 0.25 | 0.063 | 0.25 | 4 | 8 | 1 | 0.125 | 8 | 0.375 |
| Candida metapsilosis | M1879 | 0.25 | 0.063 | 0.25 | 4 | 16 | 4 | 0.25 | 4 | 0.5 |
| Candida orthopsilosis | M96926 | 0.25 | 0.063 | 0.25 | 4 | 16 | 4 | 0.25 | 4 | 0.5 |
| Candida dubliniensis | AMMRL1881 | 0.5 | 0.125 | 0.25 | 4 | 16 | 4 | 0.25 | 4 | 0.5 |
| Candida tropicalis | M230640 | 1 | 0.25 | 0.25 | 4 | 16 | 2 | 0.125 | 8 | 0.375 |
| Candida parapsilosis | ATCC22018 | 0.5 | 0.125 | 0.25 | 4 | 8 | 2 | 0.25 | 4 | 0.5 |
| Candida albicans | SC5314 | 0.25 | 0.063 | 0.25 | 4 | 16 | 2 | 0.125 | 8 | 0.375 |
| Tremellomycetes | ||||||||||
| Cryptococcus neoformans (VNI) | H99/WM148 | 0.25 | 0.063 | 0.25 | 4 | 16 | 4 | 0.25 | 4 | 0.5 |
| Cryptococcus neoformans (VNII) | WM556/RJ-64 | 0.25 | 0.063 | 0.25 | 4 | 8 | 2 | 0.25 | 4 | 0.5 |
| Cryptococcus neoformans (VNIII) | WM628 | 0.25 | 0.125 | 0.5 | 2 | 16 | 4 | 0.25 | 4 | 0.75 |
| Cryptococcus deneoformans (VNIV) | JEC20 | 0.25 | 0.063 | 0.25 | 4 | 8 | 2 | 0.25 | 4 | 0.5 |
| Cryptococcus gattii (VGI) | 2005/215 | 0.25 | 0.063 | 0.25 | 4 | 16 | 8 | 0.5 | 2 | 0.75 |
| Cryptococcus deuterogattii (VGII) | R265 | 0.5 | 0.125 | 0.25 | 4 | 16 | 8 | 0.5 | 2 | 0.75 |
| Cryptococcus bacillisporus (VGIII) | WM161 | 0.5 | 0.25 | 0.5 | 2 | 16 | 4 | 0.25 | 4 | 0.75 |
| Cryptococcus tetragattii (VGIV) | MMRL3013 | 0.25 | 0.063 | 0.25 | 4 | 16 | 4 | 0.25 | 4 | 0.5 |
a
MICX is the MIC of the agent alone, MICY is the MIC of the agent in combination, each FIC is calculated as (MICX/MICY), and FICI is the sum of FICdrug A and FICdrug B.
b
Values in bold indicate synergistic activity.