TABLE 1.
Association of HIV-1 drug resistance mutations with ETR resistancef
| Mutation | No. ETR resistant (%)a | No. ETR susceptible (%)b | Oddsc | P value | q valued |
|---|---|---|---|---|---|
| NNRTI-associated resistance mutationse | |||||
| V90I | 5 (9) | 0 (0) | Inf | 0.024 | 0.567 |
| A98G | 10 (19) | 4 (7) | 3.068 | 0.087 | 0.775 |
| L100I | 12 (23) | 1 (2) | 16.286 | 0.001 | 0.049 |
| K101H | 0 (0) | 3 (5) | 0.000 | 0.244 | 0.952 |
| K101E | 5 (9) | 5 (8) | 1.082 | 1.000 | 1.000 |
| K103N | 31 (58) | 24 (41) | 1.909 | 0.130 | 0.812 |
| K103S | 3 (6) | 3 (5) | 1.078 | 1.000 | 1.000 |
| V106M | 18 (34) | 26 (44) | 0.615 | 0.248 | 0.952 |
| V108I | 8 (15) | 5 (8) | 1.843 | 0.382 | 1.000 |
| E138A | 4 (8) | 5 (8) | 0.848 | 1.000 | 1.000 |
| E138K | 2 (4) | 1 (2) | 2.192 | 0.608 | 1.000 |
| V179D | 11 (21) | 2 (3) | 7.163 | 0.007 | 0.233 |
| Y181C | 16 (30) | 0 (0) | Inf | <0.001 | 0.001 |
| Y188L | 5 (9) | 1 (2) | 5.816 | 0.104 | 0.775 |
| G190A | 9 (17) | 17 (29) | 0.597 | 0.273 | 0.970 |
| H221Y | 6 (11) | 2 (3) | 3.500 | 0.152 | 0.901 |
| P225H | 7 (13) | 6 (10) | 1.344 | 0.769 | 1.000 |
| M230L | 10 (19) | 1 (2) | 12.955 | 0.003 | 0.174 |
| NRTI-associated resistance mutations | |||||
| M41L | 7 (13) | 10 (17) | 0.746 | 0.610 | 1.000 |
| K65R | 27 (51) | 8 (14) | 6.620 | <0.001 | 0.006 |
| D67N | 6 (11) | 11 (19) | 0.557 | 0.306 | 0.957 |
| K70R | 7 (13) | 6 (10) | 1.344 | 0.769 | 1.000 |
| Y115F | 7 (13) | 7 (12) | 1.130 | 1.000 | 1.000 |
| M184V | 41 (77) | 41 (69) | 1.500 | 0.397 | 1.000 |
| M184I | 5 (9) | 0 (0) | Inf | 0.021 | 0.605 |
a
Resistance defined as ≥2.9-fold change; n = 54.
b
Susceptibility defined as <2.9-fold change; n = 58.
c
Inf, infinite odds.
d
q value, false-discovery rate (FDR)-adjusted P value; a q value of <0.2 was considered significant.
e
NNRTI mutations K101P, V106I, E138G, V179F, V179L, V179T, Y181I, Y181V, G190E, G190S and F227G were not found in this data set.
f
Boldface type indicates resistance mutations that were significantly associated with ETR resistance.