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. 2020 Apr 21;64(5):e01980-19. doi: 10.1128/AAC.01980-19

FIG 10.

FIG 10

Transmission electron microscopy of Trypanosoma cruzi epimastigotes treated with ITZ and compound 2 for 72 h. (A) Control without treatment presents all structures preserved. (B) 100 nM ITZ; (C–E) 5 nM compound 2. Several alterations were observed, such as Golgi complex disorganization (B, GC), vacuoles similar to autophagosomes (B, C, arrow), intense disorganization and swelling of the mitochondrion (C, D, arrow), kinetoplast disorganization and swelling (D), and a flagellar membrane detachment (E). F, flagellum; GC, Golgi complex; M, mitochondrion; N, nucleus; k, kinetoplast. Bars = 0.5 μm.